Two papers by Sajobi et al. were recently published in Epilepsy & Behavior. The first, entitled, “Multivariate trajectories across multiple domains of health-related quality of life in children with new-onset epilepsy” delineated heterogeneous trajectories of quality of life in children newly diagnosed with epilepsy over a two-year period. Notably, while trajectory groups typically showed improved physical and social functioning over time, flat and worsening trajectories were seen for emotional and cognitive functioning. The second, entitled, “Response shift in children with new onset epilepsy” showed that parents of children who were newly diagnosed with epilepsy are likely to recalibrate their assessments of their children’s quality of life. The findings are relevant for assessing and interpreting health outcomes in this population of children.